Sideroblastic anaemias

The Sideroblastic Anaemias.

Sideroblastic anemia.

When first defined 50 years ago, sideroblastic anemia (SA) was already recognized to occur in heterogeneous settings, including as familial or acquired disease. The spectrum of SA has since become considerably expanded with respect to distinct clinical phenotypes as well as discrete causes. The singular feature that typifies all forms of SA and is required for initial diagnosis is the presence ...

The megaloblastic anaemias.

The Spherocytic Haemolytic Anaemias

The diagnosis of haemolytic anaemia is made when circulating red blood cell (RBC) survival is shortened. Today, the laboratory findings in haemolytic anaemia and the distinction between inherited and acquired forms are studied by preclinical medical students the world over. Although haemolytic anaemia is much less common than anaemia as a result of marrow failure or bleeding, general physicians...

Megaloblastic anaemias of gastrointestinal origin.

THERE exist two known anti-megaloblastic substances, vitamin B12 and folic acid. Both of these are absorbed from the small intestine and the body is dependent on their dietary supply to prevent abnormal changes in haemopoiesis. Deficiencies of these compounds may arise in a number of ways, but one important group arises from abnormalities of the small intestine interfering with normal absorptiv...